natural killer-cell

By Targets:	EGFR (1) Endogenous Metabolite (1) Interleukin Related (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (3)

Targets Recommended: Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Endogenous Metabolite	Inflammation/Immunology
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-P9977

Amivantamab 1 Publications Verification JNJ-61186372	EGFR	Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-N0594

Deacetylasperulosidic Acid	Interleukin Related	Inflammation/Immunology
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice . Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells .

Cat. No.	Product Name	Target	Research Area

HY-P99055

Urelumab	Inhibitory Antibodies	Inflammation/Immunology Cancer
Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .

HY-P9977

Amivantamab 1 Publications Verification JNJ-61186372	EGFR	Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-N0594

Deacetylasperulosidic Acid	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology	Interleukin Related
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice . Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells .

Species:	Human (7) Mouse (2)
Tag:	His (7) Fc (2)
Source:	HEK293 (5) E. coli Cell-free (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71231

	PRDX1 Protein, Human (His) 1 Publications Verification Peroxiredoxin-1; natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; PAGA; PAGB; TDPX2	Human	E. coli
	Peroxiredoxin-1 (PRDX1) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides and plays a crucial role in cellular protection against oxidative stress. It detoxifies peroxide and senses hydrogen peroxide-mediated signaling events. PRDX1 Protein, Human (His) is the recombinant human-derived PRDX1 protein, expressed by E. coli , with C-6His, N-6His labeled tag. The total length of PRDX1 Protein, Human (His) is 199 a.a., with molecular weight of ~27.0 kDa.

HY-P702386

	NKG7 Protein, Mouse (Cell-Free, His) Protein NKG7; natural killer cell protein 7	Mouse	E. coli Cell-free
	The NKG7 protein is an important regulator of cytotoxic granule exocytosis and mediates inflammation in infectious and non-infectious diseases. Its important roles include promoting cytotoxic degranulation of NK cells and CD8(+) T cells, activating CD4(+) T cells, and enhancing cytolytic activity through the perforin/granzyme pathway. NKG7 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived NKG7 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NKG7 Protein, Mouse (Cell-Free, His) is 165 a.a., with molecular weight of 19.5 kDa.

HY-P7796

	CD160 Protein, Human (HEK293, Fc) rHuCD160, C-Fc; CD160 Antigen; natural killer cell Receptor BY55; CD160; BY55	Human	HEK293
	CD160 Protein, Human (HEK293, Fc) is a recombinant human CD160 expressed in HEK 293 cells with a C-Fc tag at the C-terminus. CD160 Protein binds weakly to MHC I and stimulates NK and CD8⁺ T‐cell activation.

HY-P72746

	2B4/CD244 Protein, Mouse (HEK293, His) natural killer cell receptor 2B4; NAIL; NKR2B4; h2B4; SLAMF4; CD244; 2B4	Mouse	HEK293
	The CD244 protein is an activating receptor that regulates NK cells and CD8+ T cells. It enhances NK cell cytotoxicity, IFN-γ production, and granule exocytosis. 2B4/CD244 Protein, Mouse (HEK293, His) is the recombinant mouse-derived 2B4/CD244 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of 2B4/CD244 Protein, Mouse (HEK293, His) is 202 a.a., with molecular weight of 35-60 kDa.

HY-P72745

	2B4/CD244 Protein, Human (200a.a, HEK293, His) natural killer cell receptor 2B4; NAIL; NKR2B4; h2B4; SLAMF4; CD244; 2B4	Human	HEK293
	2B4/CD244 protein exhibits heightened affinity for binding to CD48, surpassing isoform 1, leading to increased cytotoxicity and intracellular calcium release. The stronger interaction implies more robust engagement, potentially amplifying cellular responses, particularly heightened cytotoxic activity and intracellular calcium release. 2B4/CD244 Protein, Human (200a.a, HEK293, His) is the recombinant human-derived 2B4/CD244 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of 2B4/CD244 Protein, Human (200a.a, HEK293, His) is 200 a.a., with molecular weight of 35-60 kDa.

HY-P71464

	Peroxiredoxin-2/PRDX2 Protein, Human (His) Epididymis secretory sperm binding protein Li 2a; HEL S 2a; MGC4104; natural killer cell enhancing factor B; natural killer cell-enhancing factor B; natural killer Enhancing Factor B; NKEF B; NKEF-B; NKEFB; Peroxiredoxin 2; Peroxiredoxin-2; PRDX 2; PRDX2; PrP; PRX2; PRXII; PTX1; TDPX1; Thiol Specific Antioxidant 1 ; Thiol specific antioxidant protein; Thiol-specific antioxidant protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Torin; TPX1; TSA	Human	E. coli
	Peroxiredoxin-2 (PRDX2) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides, which is essential for cellular protection against oxidative stress. It detoxifies peroxide, senses hydrogen peroxide-mediated signaling events, and may participate in signaling cascades initiated by growth factors and tumor necrosis factor-alpha. Peroxiredoxin-2/PRDX2 Protein, Human (His) is the recombinant human-derived Peroxiredoxin-2/PRDX2 protein, expressed by E. coli , with N-His labeled tag. The total length of Peroxiredoxin-2/PRDX2 Protein, Human (His) is 197 a.a., with molecular weight of ~25.8 kDa.

HY-P70174

	NKp46/NCR1 Protein, Human (HEK293, Fc) rHunatural Cytotoxicity Triggering Receptor 1/NCR1, Fc; natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293
	NKp46/NCR1 Protein is a major NK cell-activating receptor that is involved in the elimination of target cells and recognizing a wide range of tumors, viruses, and bacteria. NKp46 forms microclusters structures at the immune synapse between NK cells and target cells. Over-expression of human NKp46 is correlated with increased accumulation of F-actin mesh at the immune synapse. NKp46 signaling directly regulates the NK lytic immune synapse from early formation to late function. NKp46/NCR1 Protein, Human (HEK293, Fc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKp46/NCR1 Protein, Human (HEK293, Fc) is 233 a.a., with molecular weight of ~66.0 kDa.

HY-P70354

	KIR2DL3 Protein, Human (HEK293, His) rHukiller cell immunoglobulin-like receptor 2DL3/KIR2DL3, His; killer cell Immunoglobulin-Like Receptor 2DL3; CD158 Antigen-Like Family Member B2; KIR-023GB; killer Inhibitory Receptor cl 2-3; MHC Class I NK cell Receptor; NKAT2a; NKAT2b; natural killer-Associated Transcript 2; NKAT-2; p58 natural killer cell Receptor Clone C	Human	HEK293
	KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of KIR2DL3 Protein, Human (HEK293, His) is 224 a.a., with molecular weight of 35-50 kDa.

HY-P71815

	KIR2DS3 Protein, Human (P.pastoris, His) KIR2DS3; NKAT7killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; natural killer-associated transcript 7; NKAT-7	Human	P. pastoris
	KIR2DS3, present on NK cells, selectively recognizes HLA-C alleles. In contrast to inhibitory KIRs, KIR2DS3 lacks inhibitory effects on NK cell activity. Its role is likely in activating or modulating NK cell functions, contributing to the nuanced balance of signals regulating the immune response. KIR2DS3 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS3 protein, expressed by P. pastoris , with N-His labeled tag. The total length of KIR2DS3 Protein, Human (P.pastoris, His) is 224 a.a., with molecular weight of ~26.7 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80782

Peroxiredoxin 1 Antibody (YA692) PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
Peroxiredoxin 1 Antibody (YA692) is a non-conjugated and Mouse origined monoclonal antibody about 22 kDa, targeting to Peroxiredoxin 1 (6A6). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81840

Peroxiredoxin 2 Antibody (YA1585) PRDX2; NKEFB; TDPX1; Peroxiredoxin-2; natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1	WB, IHC-P	Human, Mouse, Rat

HY-P81149

NKG2D Antibody NKG2-D type II integral membrane protein; KLRK1; natural killer cell group 2D; NKG2-D isoform b; Klrk1; Nkrp2; NKG2-D-activating NK receptor; NK cell receptor D; killer cell lectin-like receptor subfamily K; NK lectin-like receptor; CD314; CD 314; CD314 antigen; D12S2489E; killer cell lectin like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K member 1; KLR; Klrk1; NKG2 D activating NK receptor; NKG2 D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D_HUMAN; NKLLR; NKR P2; Nkrp2.	WB; ELISA; IHC-P; Flow-Cyt; IF	Human, Mouse(predicted: Rat)
NKG2D Antibody is an unconjugated, approximately 25 kDa, rabbit-derived, anti-NKG2D polyclonal antibody. NKG2D Antibody can be used for: WB, ELISA, IHC-P, Flow-Cyt, IF expriments in human, mouse, and predicted: rat background without labeling.

HY-P81637

2B4 Antibody (YA1382)

CD244; 2B4; natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; CD244
FC, ELISA Human

HY-P81501

KIR2DL3 Antibody (YA1246) KIR2DL3 ; CD158B2, KIRCL23, NKAT2; CD158b2; killer cell immunoglobulin-like receptor 2DL3 ; CD158 antigen-like family member B2; KIR-023GB; killer inhibitory receptor cl 2-3; NKAT2a; NKAT2b; natural killer-associated transcript 2 (NKAT-2); p58 natural killer cell receptor clone CL-6 (p58 NK receptor CL-6); p58.2 MHC class-I-specific NK receptor	IHC-P	Human

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natural killer-cell

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